Table 1. Upregulated gene sets from previous microarray studies- Enrichment in skin from ages 18–29 to 70+.

Tissue	Study	Gender	Age of Youngest Individuals	Size	Enrichment*	Q Value
Kidney General	Rodwell et al.13	Mixed	30–45	164	2.43	0.000
Kidney Specific	Rodwell et al.13	Mixed	30–45	88	2.21	0.000
Brain	Berchtold et al.12	Male	30–45	862	1.87	0.000
Muscle	Zahn et al.15	Mixed	18–29	26	1.83	0.000
Brain	Berchtold et al.12	Female	30–45	515	1.81	0.000
Cortex (Brain)	Lu et al.16	Mixed	30–45	137	1.63	0.006
Muscle	Welle et al.14	Male	1829	76	1.47	0.026

Gene sets were constructed from lists of genes identified as significantly increasing in expression with age in previous studies. Using GSEA these gene sets were then assessed for their level of enrichment within expression data from human skin.

^*A score of 0 indicates no enrichment.