Table 3. Summary of systematic reviews and meta-analyses evaluating the diagnostic accuracy of D-dimer for acute aortic dissection.
| Author (Year) | Studies | Subjects | Model | Cutoff (ng/ml) | Quality assessment | Sensitivity analysis | Diagnostic odds ratio | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|---|---|
| Sodeck10 | 16 | 437 | Random-effect | 100–900# | QUADAS | Done | 21.27 | 0.94 | 0.97 | 0.59 |
| Marill7 | 11 | 541 | Fixed-effect | 500 | NA | NA | NA | NA | 0.94 | 0.95 |
| Brown50 | 7 | 744 | Not specified | 500 | NA | NA | NA | NA | 0.97 | 0.56 |
| Shimony6 | 7 | 744 | Random-effect | 500 | QUADAS | NA | NA | NA | 0.97 | 0.56 |
| Shao29 | 9 | 1337 | Random-effect | 500 | NA | NA | NA | 0.88 | 0.89 | 0.68 |
| Cui8 | 5 | 743 | Random-effect | 170–5000# | NOQAS | Done | NA | 0.92 | 0.945 | 0.691 |
| Asha9 | 4 | 1557 | Random-effect | 400–500# | QUADAS/STARD | NA | NA | NA | 0.980 | 0.419 |
| Watanabe | 22 | 5000 | Hierarchical | 246–8700# | QUADAS-2 | Done | 28.5 | 0.946 | NA | NA |
| Watanabe | 12 | 2827 | Hierarchical | 500 | QUADAS-2 | Done | 30.7 | 0.950 | 0.952 | 0.604 |
#using a range of cutoff values collectively.
QUADAS: the Quality Assessment of Diagnostic Accuracy Studies.
QUADAS-2: the Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies.
STARD: the Standards for Reporting of Diagnostic Accuracy.
NOQAS: the Newcastle-Ottawa Quality Assessment Scale.
NA: not assessed.
AUC: area under (hierarchical) summary receiver operating characteristics curve.