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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Biomaterials. 2016 Apr 26;97:22–33. doi: 10.1016/j.biomaterials.2016.04.029

Fig. 9.

Fig. 9

Therapeutic efficacy of the TDP-A-loaded micelles in the subcutaneous BON cell xenografts. Each mouse received five intravenous injections (3.125 mg/kg BW) spaced 4 days apart. (A) In vivo anticancer efficacy of different TDP-A formulations in BON tumor xenografts. (B) Change in the body weight of animals as a function of time. All values are presented as a mean SD (n = 7); **: P < 0.01; ***: P < 0.001; NS: not significant. Note: Three mice died in the FK228 group due to the severe toxicity of FK228. (C) Representative H&E-stained sections of brain, heart, liver, and leg muscles of a mouse treated with the control (baseline) and TDP-A-loaded targeted micelles. No signs of apoptotic or necrotic areas were observed for the TDP-A-loaded targeted micelles.