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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):26–34. doi: 10.1002/cmmi.460

Figure 4.

Figure 4

The dependence of CEST on pH. The percentage CEST effects of the (A) amide and (B) amine of 30 mm of Yb–DO3A–oAA were measured at 38.3°C using 10 µT saturation power. Error bars represent the standard deviation of three repetitions, and some error bars are smaller than the data symbol. (C) The log10 of the ratio of CEST showed an excellent correlation with pH (R2 = 0.88 and a standard deviation of 0.21 pH units). The pH of subsequent studies was determined from this correlation, pH=6.34–2.82 (log10{[(M0−MS)/M0]amide/[(M0−MS)/M0]amine}).