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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):26–34. doi: 10.1002/cmmi.460

Figure 5.

Figure 5

Validation of pH measurements. (A) The pH measured with CEST of Yb–DO3A–oAA at 38.3°C had outstanding agreement with the pH measured with MR spectroscopy of IEPA (slope = 1.00, R2 = 0.99, standard deviation = 0.09 pH units) at the same temperature. (B) The pH measured with MR spectroscopy of IEPA had excellent agreement with the pH measured with an electrode (slope =0.92, R2 = 0.996, standard deviation = 0.079 pH units), indicating that the presence of Yb–DO3A–oAA did not affect the chemical shift of IEPA.