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. 2015 Nov 20;159(1):9–15. doi: 10.1093/jb/mvv113

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© The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved

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Fig. 3 — A proposed model of the regulation of maintenance DNA methylation through Uhrf1-mediated H3K23 and/or H3K18 ubiquitylations. After DNA replication, existing fully methylated DNA cannot be replicated by a canonical DNA replication system, generating hemi-methylated DNA. Uhrf1 specifically binds to hemi-methylated DNA and ubiquitylates H3K23 and/or H3K18. Ubiquitylations of H3K23 and/or H3K18 specifically recruit Dnmt1 at the sites of DNA replication. The recruited Dnmt1 then catalyzes the conversion of hemi-methylated DNA to fully methylated DNA.