Table 2. Relationships of cIMT and fasting TMAO levels with selected parameters at baseline.
TMAO levels | cIMT | |||
---|---|---|---|---|
r | p | r | p | |
Age | 0.23 | 0.0006 | 0.64 | <0.0001 |
Body mass index | 0.14 | 0.03 | 0.19 | 0.004 |
Total body fat MRT | 0.07 | 0.27 | 0.06 | 0.42 |
Visceral fatMRT | 0.12 | 0.07 | 0.40 | <0.0001 |
Liver fatMRS | 0.05 | 0.45 | 0.23 | 0.0005 |
Fasting glucose | 0.15 | 0.02 | 0.25 | 0.0002 |
Fasting insulin | 0.02 | 0.72 | 0.12 | 0.07 |
2 hr glucose | −0.08 | 0.25 | 0.18 | 0.008 |
Total cholesterol | 0.14 | 0.04 | 0.17 | 0.01 |
HDL-cholesterol | 0.01 | 0.84 | −0.12 | 0.08 |
LDL-cholesterol | 0.14 | 0.03 | 0.12 | 0.005 |
Triglycerides | 0.07 | 0.29 | 0.12 | 0.07 |
Apolipoprotein B | 0.18 | 0.009 | 0.27 | <0.0001 |
Hs-CRP | −0.01 | 0.88 | 0.13 | 0.06 |
TNF-alpha* | 0.27 | 0.001 | 0.10 | 0.22 |
Systolic BP | 0.006 | 0.93 | 0.19 | 0.005 |
Diastolic BP | −0.005 | 0.94 | 0.12 | 0.09 |
eGFR | −0.14 | 0.04 | −0.06 | 0.36 |
HOMA-IR | 0.05 | 0.48 | 0.15 | 0.02 |
Insulin sensitivityOGTT | −0.002 | 0.98 | −0.18 | 0.009 |
Insulin sensitivityClamp# | −0.03 | 0.75 | −0.13 | 0.10 |
Insulin clearance | 0.03 | 0.62 | −0.11 | 0.12 |
r, Pearson correlation coefficient; *Only available in 144 subjects. #Only available in 167 subjects. BIA, body impedance; MRT, magnetic resonance tomography; MRS, magnetic resonance spectroscopy. MRT: magnetic resonance tomography, MRS: magnetic resonance spectroscopy; eGFR: estimated glomerular filtration rate; HOMA-IR: homeostatic model assessment of insulin resistance; cIMT: carotid intima-media thickness; TMAO: trimethylamine N-oxide; BP: blood pressure.