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. 2016 May 13;8(5):291. doi: 10.3390/nu8050291

Figure 2.

Figure 2

Suboptimal vitamin D status directly and indirectly contributes to the development and progression of cognitive impairment. Studies have demonstrated an association of hypovitaminosis D and diseases that raise vascular risks [85]. Endothelial dysfunction and inflammatory/uremic milieu in CKD act not only as a consequence of CKD but also through promoting vascular risk factors contributing the CKD progression.