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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: Annu Rev Neurosci. 2015 Apr 22;38:331–349. doi: 10.1146/annurev-neuro-071714-034145

Figure 2.

Figure 2

Unfolded protein response (UPR)-mediated olfactory receptor (OR) feedback. ❶ Histone demethylation by LSD1 activates an OR gene. ❷ As the OR is being translated, it activates the PERK branch of the UPR. ❸ This activation results in EIF2A phosphorylation and Atf5 translation. ❹ ATF5 activates Adcy3 transcription, and ❺ ADCY3 then prevents further LSD1 activity. ❻ ATF5 also activates Rtp1 transcription. ❼ RTP1 suppresses further UPR activation. ER, endoplasmic reticulum.