Table 4.
Diabetic patients stratified by statin use prior to first myocardial infarction
| On statins before MI | Not on statins before MI | p value | |
|---|---|---|---|
| n = 106 | n = 122 | ||
| Gender, % | – | – | 0.51 |
| Age, year | 70.1 (12.0) | 70.6 (15.2) | 0.80 |
| Smoking, % | 34 | 37 | 0.21 |
| Total cholesterol, mmol/L | 4.1 (1.2) | 4.8 (1.4) | <0.001 |
| LDL cholesterol, mmol/L | 2.1 (0.9) | 2.9 (1.2) | <0.001 |
| HDL cholesterol, mmol/L | 1.2 (0.4) | 1.2 (0.4) | 0.42 |
| Triglycerides, mmol/L | 1.8 (1.6) | 1.9 (1.3) | 0.45 |
| Systolic blood pressure, mmHg | 139 (21.5) | 138 (24.0) | 0.76 |
| Hypertension, % | 89 | 71 | 0.001 |
| Antihypertensive medicine, % | 79 | 60 | 0.002 |
| GFRc, mL/min/1.73 m2 | 64 (27.3) | 72 (27.3) | 0.03 |
| Nephropathy (GFR < 60)c, % | 43 | 33 | 0.69 |
| Family history of CHD, % | 37 | 34 | 0.62 |
| LDL cholesterol ≥2 mmol/L, % | 54 | 81 | <0.001 |
| LDL cholesterol ≥1.8 mmol/L, % | 57 | 83 | <0.001 |
| SCORE (mean), % | – | 3.8 (2.8) | |
| SCORE (mean) before statin therapya, % | 4.6 (3.8) | – | |
| Estimated 10-year risk in diabetes (mean)b, % | 16.6 (12.4) | 13.7 (10.2) | 0.10 |
| Estimated 10-year risk in diabetes ≥5 %b, n/n | 91 % | 85 % | 0.22 |
Baseline characteristics are provided as mean (standard deviation) for continuous values
aSCORE was calculated after adding 1.5 mmol/L to the measured on-treatment total cholesterol concentration (an estimate of the pre-treatment SCORE risk)
bSCORE risk multiplied by 3 in men and 5 in women to take the diabetes-related risk into account [5, 6, 15]
c GFR glomerular filtration rate; GFR < 60 mL/min/1.73 m2 is defined as moderate-to-severe chronic kidney disease in the ESC guideline [6]