Fig. 2.

Histological analyses of PAS-stained renal sections from 16-week-old mice. a Representative glomerular and cortical sections. ICGN: entire expansion of the mesangial matrix and vascular dilations (score 5), massive tubular dilations with urinary casts and cell infiltrations. ICGN-Chr 2^B6: partial expansion of the mesangial matrix and vascular stenoses (score 3). ICGN-Tns2 ^WT: nearly normal (upper, score 0), partial expansion of the mesangial matrix and vascular wall thickening (lower, score 2). b The mean ratio of the glomerular injury scores each sample. c Glomerular injury index and tubular injury index. Asterisks indicate P-values for Dunn’s multiple comparison test, ** <0.01 and * <0.05 vs. ICGN mice. Error bars represent standard error. Eleven ICGN mice, four ICGN-Chr 2^B6 mice and three ICGN-Tns2 ^WT mice were analyzed