Table 3.

Gene ontology (GO) enrichment of statistically significant (FDR < 0.15) GO terms for the Ugandan ecotypes

Population	GO ID	Gene ontology term	Genes under GO term	Related environmental stressor(s)	Reference
Ugandan Ecotypes	GO:0065008	Regulation of biological quality	PDIA5, CADPS2, TNIP2, CNOT6L, DISP3, ABCA4, PRKCA, SIN3A, PEX11A, DLG1, MC4R, RC3H1, NPY, SMAD1, CNGA2, RCOR1, RAP1GDS1, NAT8L, BICD2, SYNE1, ATP9A, STX12	Growth response to Environmental Stress	UniProt [67], Jenuth 2000 [69, 77]
	GO:0001816	Cytokine production	DLG1, TRIB2, MAP3K7, EIF2AK2, SNAI2	Pathogen/Predator	Welc et al. 2013 [56]
	GO:0043122	Regulation of I- kappaB kinase/NF-kappaB signaling	TNIP2, ZFAND6, ZDHHC17, MAP3K7	Inflammation/Oxidative Stress	Evans et al. 2002 [46], Perkins et al. 2007 [55] Salminen et al. 2008 [87], Tam et al. 2012 [88]
	GO:0016627	Oxidoreductase activity, acting on the CH-CH group of donors	TECRL, DYPD	Oxidative stress	UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
	GO:0005215	Phospholipid transporter activity	ABCA4, ATP9A	Lipid Metabolism, phospholipid transfer to membrane	UniProt [67], Jenuth 2000 [69, 77]
	GO:0080134	Regulation of response to stress	TNIP2, PSMB4, MAP3K7, SIN3A, MID1, EIF2AK2, SNAI2	Oxidative/Metabolic/Environmental Stress	UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
	GO:1901224	Positive regulation of NIK/NF-kappaB signaling	RC3H1, MAP3K7, EIF2AK2	Inflammation/Oxidative Stress	Evans et al. 2002 [46], Perkins et al. 2007 [55], Salminen et al. 2008 [87], Tam et al. 2012 [88]
	GO:0031098	Stress-activated protein kinase signaling cascade	MAP3K7, MID1, EIF2AK2	Oxidative/Environmental Stress	Li et al. 2011 [70], Yen et al. 2014 [90]
	GO:0006915	Apoptotic process	TNIP2, SUDS3, ROBO1, ZFAND6, DNAJC5, MAP3K7, LCMT1, SIN3A, GRK5, EIF2AK2, SHQ1, CHL1, COMP, LFABP, SNAI2	Oxidative/Environmental Stress	Galvez et al. 2001 [47]
	GO:0032874	Positive regulation of stress-activated MAPK cascade	MAP3K7, MID1, EIF2AK2	Oxidative/Environmental Stress	UniProt [67], Jenuth 2000 [69, 77]
	GO:0006950	Response to stress	PDIA5, CADPS2, TNIP2, PSMB4, MAP3K7, UBE2T, SIN3A, EIF2AK2, MMP7, CXCR4, MID1, PAX-7, LFABP, SMAD1, SNAI2	Oxidative/Environmental Stress	UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
	GO:0009719	Response to endogenous stimulus	MC4R, GRB10, DISP3, MAP3K7, SMAD1, STMN2, SNAI2	Oxidative/Environmental Stress	Evans et al. 2002 [46]
	GO:0034976	Response to endoplasmic reticulum stress	PDIA5, EIF2AK2	Oxidative/Environmental Stress	Evans et al. 2002 [46], Zhang et al. 2008 [54]