Table 5.

Gene ontology (GO) enrichment of statistically significant (FDR < 0.15) GO terms for the Kuroilers

Population	GO ID	Gene ontology term	Genes under GO term	Related environmental stressor(s)	Reference
Kuroilers	GO:0060584	Regulation of prostaglandin-endoperoxide synthase activity	EDN2, EDN1	Oxidative stress/Pathogen	Lee et al. 2007 [89]
	GO:0007631	Feeding behavior	HCRTR2, HTR1B, GRIN1, NPY1R, ASIP	Nutrient stress	UniProt [67], Jenuth 2000 [69, 77]
	GO:0032693	Negative regulation of interleukin-10 production	TRIB2, IL-12B	Pathogen	UniProt [67], Jenuth 2000 [69, 77]
	GO:0051341	Regulation of oxidoreductase activity	ACVR2A, EDN2, EDN1, SNCA	Oxidative stress/Pathogen	UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
	GO:0007618	Mating	ACVR2A, SERPINE2, GRIN1	Survival Behavior	UniProt [67], Jenuth 2000 [69, 77]
	GO:0016627	Oxidoreductase activity, acting on the CH-CH group of donors	IVD, CPOX, ACAD9, DHCR24	Oxidative/Environmental Stress	UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
	GO:0006950	Response to stress	ENTPD1, ETFDH, WNT5A CHID1, RBBP5, NEDD4, NSMCE2, GLP1R, STX2, LEAP2, RAB23, DEAF1, TNFSF11, PPP2R5C, DRD4, ZC3HAV1, CDH8, PPAP2B, GTF2H5, MCPH1, EDN1, FAM175B, GCLM, JAK1, UBXN2A, MID1, BATF, CPEB2, IL12B, PIK3AP1, SOX2, SNCA, CITED2, CHAC1, DTL, HIPK3, NOS1, STT3B, PDIA4, SBNO2, NUAK1, CDC7, SERPINE2, ULK1, MASP2, WFS1, DHCR24, PRKD1	Oxidative/Metabolic/Environmental Stress	UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
	GO:0080134	Regulation of response to stress	WNT5A, CHID1, PIK3AP1, IL12B, STX2, SNCA, HIPK3, TNFSF11, ZC3HAV1, PPAP2B, SBNO2, NUAK1, MCPH1, EDN1, SERPINE2, ULK1, WFS1, MID1	Oxidative/Metabolic/Environmental Stress	UniProt [67], Puvadolpirod et al. 2000 [48], Li et al., 2011, Yen et al., 2014
	GO:0033554	Cellular response to stress	WNT5A, RBBP5, BATF, CPEB2, NEDD4, NSMCE2, SNCA, CHAC1, CITED2, DTL, HIPK3, RAB23, TNFSF11, PPP2R5C, PDIA4, GTF2H5, NUAK1, FAM175B, EDN1, CDC7, ULK1, WFS1, UBXN2A, MID1, PRKD1	Oxidative/Metabolic/Environmental Stress	UniProt [67], Puvadolpirod et al. 2000 [48]
	GO:0045859	Regulation of protein kinase activity	TNFSF11, DRD4, WNT5A, TGFBR2, RAPGEF2, PDGF, PIK3CA, KIAA1199, LATS2, IL12B, EDN1, PAQR3, SNCA, GTPBP4, HIPK3	Oxidative/Metabolic/Environmental Stress	UniProt [67], Jenuth 2000 [69, 77]
	GO:0003100	Regulation of systemic arterial blood pressure by endothelin	EDN2, EDN1	Oxidative/Metabolic Stress	Endemann et al. 2004 [20], Gomez et al. 2007 [21]
	GO:0048010	Vascular endothelial growth factor receptor signaling pathway	FIGF, NEDD4, GRB10, PRKD1	Oxidative/Metabolic Stress	Koch et al., 2012 [57]
	GO:0004674	Protein serine/threonine kinase activity	CDC42BPB, DCLK1, TGFBR3, TGFBR2, PRKCA, LATS2, ACVR2A, NUAK1, CDC7, ULK1, CDC2L1, HIPK3, VRK1, PRKD1	Oxidative/Metabolic/Environmental Stress	UniProt [67], Evans et al. 2002 [46], Perkins et al. 2007 [55], Salminen et al. 2008 [87], Tam et al., 2012 [88]
	GO:0009628	Response to abiotic stimulus	GPR65, GRIN1, CASP8, IL12B, CPEB2, SOX2, NEDD4, TNFRSF8, CITED2, DTL, ER81, NOS1, DEAF1, CNGA2, CDH8, MME, GTF2H5, HR1B, SERPINE2, EDN1, FAM175B	Oxidative/Metabolic/Environmental Stress	Mashaly et al. 2004 [92], Mujahid et al. 2005 [16]
	GO:0004672	Protein kinase activity	CDC42BPB, DCLK1, PRKCA, HIPK3, VRK1, ROR1, TRIB2, TGFBR3, TGFBR2, LATS2, ACVR2A, NUAK1, CDC7, ULK1, CDC2L1, PEAK1, JAK1, RPS6KC1, PRKD1	Oxidative/Metabolic/Environmental Stress	UniProt [67], Jenuth 2000 [69, 77]