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. 2016 May 26;14:153. doi: 10.1186/s12957-016-0908-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — a The control group was positive for endothelial cell UEAI expression (endothelial cell marked with arrows, ×400 HPF). b The HIFU group was negative for endothelial cell UEAI expression (×400 HPF). c The average tumor capillaries, venules, and arterioles amount together 17.20 ± 3.50/vessels/HPF for the control group; vascular structure was destroyed for the HIFU group, with a vascular amount 0; UEAI staining was positive in control group, microvessel density count (MVD) was 51.18 ± 9.56/vessels/HPF, and UEAI staining was negative for the HIFU group, with a MVD of 0; the expression of vascular endothelial growth factor (VEGF) expression for the control group and HIFU group were 10.23 ± 2.20 and 1.31 ± 0.65, respectively; VEGF expression for the HIFU group remarkably decreased