Table 1.

Functions of genes which show a significant correlation between DNA methylation and gene expression. The majority of genes were hypomethylated and up-regulated in pilocytic astrocytomas compared to diffuse astrocytomas, except the three genes highlighted in bold

MAPK pathway and downstream targets: DUSP5 FOS MIR21 CDK6 Tumour suppressors: AIM1 OPCML MCC IRX1 Multidrug resistance: ABCC3 Inflammation: SOCS3 IL6ST CD59 Other: FAM89A FAM167A PRSS23 WSCD1 STAMBPL1 TMEM169

Receptors and channels: HRH1 LDLRAD3 RARRES1 IGF1R GRIA4 CHRM3 TRPM8 KCND2 GJA1 Cell morphology, motility and interactions: MDGA2 TM4SF1 TMEM132C IGSF9B KIRREL3 LEPREL1 TMEM49 COTL1 PTPRE