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. 2016 May 26;16:335. doi: 10.1186/s12885-016-2374-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Interactome map of proteins involved in ALL and their partners (a) Literature curation of interactions between the 116 proteins mutated in ALL (grey nodes) and their human partners (purple nodes). b Interactions identified by high throughput Y2H screen. Cancer census gene encoded proteins are represented in grey and their partners in green. c The graph represents a ranking 37 candidates among the ALL-related partners based on the number of interactions between human proteins and ALL related proteins. In addition these genes are among the cancer gene census and they are expressed in 60 % of ALL-cell lines (purple bars represent literature-curated interactors and green bars represent Y2H interactors). The X-axis represents gene symbols; the Y-axis represents the number of partners. d Interactions between the 37 identified ALL-candidate genes and their partners among the ALL gene census