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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: Cancer Genet. 2015 Mar 18;208(6):345–350. doi: 10.1016/j.cancergen.2015.03.005

Figure 2.

Figure 2

Genetic heterogeneity within a high-grade meningioma. (A) High-resolution aCGH was performed on DNA extracted from core punches taken from area 1 (WHO grade I), area 2 (WHO grade II), and area 3 (WHO grade III), using 1×1M Agilent SurePrint G3 Human CGH Microarray chip [3,30]. Red indicates gain and blue indicates loss. (B) Copy number analysis from exome-sequencing data of the three areas shown as allelic copy ratios. Red indicates gain and blue indicates loss. (C) In situ hybridization of TERT mRNA transcripts using a TERT-specific RNAscope probe in FFPE sections of the meningioma samples [10,14]. (D) Immunohistochemistry for ARID1A. (E) Schematic representation of clonal evolution leading to dedifferentiation and intratumoral heterogeneity. Scale bar, 10 μm.