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. 2016 Feb 29;20(6):1182–1190. doi: 10.1111/jcmm.12818

Figure 4.

Figure 4

Effect of colchicine on the protein expression of calcium (Ca2+) regulatory proteins and potassium channel proteins. (A) Representative immunoblotting and average data of sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), Cav1.2, Ca2+/calmodulin‐dependent protein kinase II (CaMKII), PLB, Ser16‐ and Thr17‐phosphorylated PLB (PLB‐Ser16 and PLB‐Thr17) from control and colchicine (3 nM)‐treated HL‐1 cells. (n = 9) (B) Representative immunoblotting and average data of RyR type 2, phosphorylation of RyR at S2808 and S2814 (RyR‐2808 and RyR‐2814), the Na+–Ca2+ exchanger (NCX), Kv1.4, Kv1.5 and Kv4.2 from control and colchicine (3 nM)‐treated HL‐1 cells (n = 7). *P < 0.05 versus the control. PLB, phospholamban; RyR, ryanodine receptor.