Figure 2.

S1P and apoM in lethal sepsis. Baboons (n = 8) were challenged with 1–2 × 10¹⁰ cfu/kg of E. coli (LD ₁₀₀). Blood samples were collected at intervals from time‐point zero to 24 hrs post‐infusion except for from the baboons that had to be sacrificed earlier. S1P was measured by LC‐MS/MS, apoM and apoA1 by ELISA, albumin, HDL‐cholesterol and LDL‐cholesterol by commercial kits, and apoE by Western blotting (values being given relative to time‐point zero). Data are presented as individual values for each baboon. Statistical analysis of differences between time‐points was performed with a Durbin–Skillings–Mack test.