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Signaling mechanisms downstream of pro-NGF that induce growth cone collapse. Pro-NGF binds to a receptor complex containing p75NTR and SorCS2 on cultured hippocampal neurons. This causes Trio, a guanine exchange factor for Rac GTPase, to be released from the receptor complex. Consequent reduction of Rac activity, together with protein kinase C (PKC)–dependent phosphorylation and inactivation of the actin-bundling protein fascin, leads to actin disassembly and growth cone collapse.
