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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: J Am Chem Soc. 2015 Mar 5;137(10):3600–3609. doi: 10.1021/jacs.5b00022

Figure 4.

Figure 4

Active site plasticity: a view from molecular modeling. The observed switch in facial selectivity as a function of substrate class with preservation of high facial selectivity is evidence of unusual active site plasticity in CaADH. Note: The coordinates of the NADPH-cofactor (background) were imported from PDB-1XG5.