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. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: Fitoterapia. 2015 Oct 30;107:114–121. doi: 10.1016/j.fitote.2015.10.011

Table 3.

In vitro antitrypanosomal activities of triterpenoid saponins isolated from Mussaenda luteola against Trypanosoma brucei brucei.

Compound Antitrypanosomal activity
 THP1 cell toxicity
IC50 μg/mL (μM) IC90 μg/mL (μM) IC50 (μg/mL)
DFMO 2.38 (13.06) ± 0.43 5.28 (28.99) ± 0.24 >10
1 9.13 (8.80) ± 0.64 11.05 (10.60) ± 0.82 >10
2 3.08 (2.57) ± 0.64 4.27 (3.56) ± 1.12 >10
3 2.75 (2.61) ± 0.09 3.53 (3.36) ± 0.10 >10
4 3.04 (2.84) ± 0.39 4.64 (4.35) ± 1.70 >10
5 >10 >10 >10

DFMO, Difluromethylornithine; IC50 and IC90 values are mean ± S.D. of duplicate observations.

The IC50 and IC90 values were computed from dose–response curves presented in Fig. 3. The tested concentrations range (0.4–10 μg/mL).