Table 8.

Six key high-risk medicines to target in regular medication reviews

High-risk medicine	Suggested action
Triple whammy combination (NSAID, diuretic, ACE inhibitor)	Stop NSAID
NSAID + reduced renal function	Stop NSAID
NSAID + age >75 + no PPI	Stop NSAID or add PPI
Hypnotic/benzodiazepine + age >60	Reduce or stop hypnotic/ benzodiazepine
Tricyclic antidepressant + age >60	Reduce or stop tricyclic antidepressant
Antipsychotic + age >60	Reduce or stop antipsychotic

NSAID non-steroidal anti-inflammatory drug, ACE inhibitor angiotensin converting enzyme inhibitor, PPI proton pump inhibitor