Fig. 2.

The LP17 inhibitory peptide dampens anti-GBM nephritis in 129/SvJ mice. Anti-GBM-induced mice were randomly divided into three treatment groups (n = 5) as in Fig. 1e, f. a An example of tissues from the three treatment groups is shown. Tissues were examined terminally for b glomerulonephritis (GN) score, c percent crescent formation, and d tubulointerstitial nephritis (TI) score. e Examples of tissues prepared from the three treatment groups examined for inflammatory cells (upper panel) or macrophages (lower panel). f Inflammatory cell infiltrate scores and g interstitial macrophage counts are shown at day 21 after receiving anti-GBM serum. Statistical analysis was carried out by Mann-Whitney U tests to obtain the P values shown.