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. Author manuscript; available in PMC: 2016 Nov 11.
Published in final edited form as: Nature. 2016 May 11;533(7604):539–542. doi: 10.1038/nature17671

Extended Data Figure 4. Replication of 74 lead SNPs in the UK Biobank data.

Extended Data Figure 4

Estimated effect sizes (in years of schooling) and 95% confidence intervals of the 74 lead SNPs in the meta-analysis sample (N = 293,723) and the UK Biobank replication sample (N = 111,349). The reference allele is the allele associated with higher values of EduYears in the meta-analysis sample. SNPs are in descending order of R2 in the meta-analysis sample. Of the 74 lead SNPs, 72 have the anticipated sign in the replication sample, 52 replicate at the 0.05 significance level, and 7 replicate at the 5×10−8 significance level.