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. 2016 Feb 24;9(5):1303–1316. doi: 10.1038/mi.2015.137

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© The Author(s) 2016

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/

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1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine (SAPS) modulates TRIF- and MAVS-dependent activation of the CXCL8 and IFN-β promoters. BEAS-2B cells were transfected with plasmids encoding ΔTRIF and MAVS. After 6 h, transfected cells were treated with the indicated SAPS concentrations and cell lysates were generated at 24 h. ΔTRIF (a, b) or MAVS (c, d) induced CXCL8 (a, c), and IFN-β (b, d) reporter activation relative to empty vector control pUNO1 was measured. Data shown are mean±s.e.m. (n=2 for a and b, and n=5 for c and d). Reporter data are presented as fold induction vs. control. Significant differences are indicated by *P<0.05.

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