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. 2013 Jun 25;6:16. doi: 10.1186/1939-8433-6-16

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© Itai et al.; licensee Springer. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Putative scheme of SAM supply for MAs synthesis and expression changes in the involved genes. A) Biosynthetic pathway of the Met cycle and its collaborative pathways. Enzymes are shown in bold. MTA, methylthioadenosine; MTR, methylthioribose; MTR-1-P, methylthioribose-1-phosphate; MTRu-1-P, methylthioribulose-1-phosphate; KMTP, 1,2-dihydroxy-3-keto-5-methylthiopentene; KMTB, 2-keto-4-methylthiobutyrate; PRPP, phosphoribosyl pyrophosphate; SAMS, SAM synthetase; MTN, methylthioadenosine nucleosidase; MTK, methylthioribose kinase; IDI1, acireductone dioxygenase; IDI2, methylthioriburose-1-phosphate isomerase; DEP, dehydrase-enolase-phosphatase; IDI4, aspartate/tyrosine/aromatic aminotransferase; APRT, adenine phosphoribosyltransferase; PRPPS, PRPP synthetase; RPI, ribose 5-phosphate isomerase; FDH, formate dehydrogenase. B) Expression changes of Met cycle-related genes.