Table 2. List of metabolites that were altered significantly in unhealthy compared to healthy rhino serum samples after FDR correction.
| Metabolitesa | Binb | P valuec | Changesd | |
|---|---|---|---|---|
| (ppm) | (FDR Corr) | Function | ||
| Ile | 1.015 | 1.02E-11 | ↓ | Essential amino acid, BCAA, protein catabolism |
| Val | 1.055 | 8.10E-10 | ↓ | Essential amino acid, BCAA, protein catabolism |
| Gly | 3.565 | 2.59E-03 | ↓ | Amino acid metabolism |
| Leu | 0.955 | 1.04E-05 | ↓ | Essential amino acid, BCAA, protein catabolism |
| Gln | 2.145 | 3.46E-05 | ↑ | Amino acid metabolism |
| Asn | 2.885 | 1.74E-03 | ↓ | Amino acid metabolism |
| Ala | 1.475 | 9.02E-05 | ↑ | Amino acid metabolism |
| Phe | 7.325 | 9.61E-06 | ↑ | Essential amino acid, AAA, |
| Mannose | 5.185 | 9.57E-07 | ↑ | Carbohydrate sugar, Glycoprotein |
| Glucose | 5.235 | 1.55E-03 | ↓ | Carbohydrate sugar |
| Creatine | 3.045 | 5.21E-03 | ↓ | Creatinine synthesis in liver |
| Phosphocreatine | 3.055 | 1.00E-07 | ↓ | Creatinine synthesis in liver |
| Creatinine | 4.065 | 1.81E-06 | ↓ | Creatinine synthesis in liver |
| Pyruvate | 2.375 | 2.20E-05 | ↑ | Krebs cycle |
| Citrate | 2.525 | 2.41E-08 | ↓ | Krebs cycle, Fatty acid synthesis |
| Lactate | 4.105 | 5.25E-07 | ↑ | Krebs cycle |
| 2-Hydroxyisobutyrate | 1.365 | 8.61E-08 | ↓ | |
| Acetate | 1.925 | 1.71E-06 | ↓ |
a Ile: isoleucine, Val: valine, Gly: glycine, Leu; leucine, Gln: glutamine, Asn: asparagine, Ala: alanine, Phe: phenylalanine.
b The chemical shift of the bin used for the p value calculation.
c The FDR corrected alpha values.
d Increased (↑) and decreased (↓)in unhealthy samples compared to healthy samples.