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. 2016 May 23;11:2235–2250. doi: 10.2147/IJN.S100404

Figure 11.

Figure 11

Polymeric prodrugs of BUF lead to enhanced antitumor efficacy in the BALB/c nude mice bearing MCF-7.

Notes: Saline, P(OEGMA-co-BSMA), BUF, P(OEGMA-co-BUF), and P(OEGMA-co-BUF-co-Oct) were administered by intravenous injection into the mice. (A) The final tumor weight, (B) body weight, (C) tumor volume, and (D) tumor images were examined. Student’s t-test was performed between samples P(OEGMA-co-BUF-co-Oct) and P(OEGMA-co-BUF) (*P<0.05); between P(OEGMA-co-BUF) and free BUF (**P<0.05); between free BUF and P(OEGMA-co-BSMA) (***P<0.05). Data reported as mean ± standard deviation.

Abbreviations: BUF, bufalin; OEGMA, oligo(ethylene glycol) monomethyl ether methacrylate; BSMA, 3-((2-(methacryloyloxy)ethyl)thio) propanoic acid; Oct, octreotide.