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. 2014 Nov 12;4:60. doi: 10.1186/s13550-014-0060-4

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© Sharma et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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PET images and diagrams. (A-E, G-I) Representative 24-h post-injection small-animal-PET images of xenograft mice injected with radioimmunoconjugates. (F) 1-h p.i. PET image of NIH:OVCAR-3 xenograft mouse injected with ¹⁸ F-FDG. Color intensity scale bars represent standardized uptake value (SUV) of radiotracer in animals. Diagrams on the right show (J) SUV in tumors of experimental and control animals using ⁶⁴Cu-labeled anti-CA125 MAb, (K) SUV in NIH:OVCAR-3 tumors after correction for non-specific uptake, (L) tumor SUV obtained from injection of ⁶⁴Cu-labeled anti-CA125 MAb in NIH:OVCAR-3 versus SKOV3 xenograft mice, and (M) tumor SUV obtained from injection of ⁶⁴Cu-labeled anti-CA125 scFv in NIH:OVCAR-3 versus SKOV3 xenograft mice. Numbers of animals (n) are indicated at the bottom of each bar.