Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Cancer Immunol Res. 2016 Feb 15;4(4):354–365. doi: 10.1158/2326-6066.CIR-15-0241

Figure 3. Overexpression of mutant KRASG12V in wild-type KRAS tumor cells induced Treg conversion.

Figure 3

(A) The percentage of FOXP3+ T lymphocytes, (B) the suppressive ability, and (C) the percentage of cells expressing intracellular IL10 and TGFβ1 in T cells generated with WT KRAS tumor cells overexpressing mutant KRASG12V plasmid (KRAS Pd) was significantly higher than WT cells. Data are means ± s.d. from three independent experiments, *P < 0.05, ** P < 0.005 (compared to untransfected Colo320 cells; Student’s t-test).