Table 1.

Advantages and disadvantages of anti-cancer therapies targeting macrophage behaviors

Approach	Advantages	Disadvantages
Anti-angiogenic therapy	Inhibit tumor growth and prevent metastasis [33],[34], improves efficacy of chemotherapeutics [35]	Must be used in combination with chemotherapeutics [36]; systemic effects [36],[37]
Recruitment inhibition	Prevent macrophages from entering tumor, becoming TAMs [38],[39]	Systemic effects [38]
Macrophage reprogramming	Macrophages secrete tumoricidal molecules [40],[41]	Local delivery necessary to avoid altering systemic Th1/Th2 paradigm [42]