. Author manuscript; available in PMC: 2016 May 27.

Published in final edited form as: Lancet Haematol. 2015 Apr 20;2(5):e186–e193. doi: 10.1016/S2352-3026(15)00048-4

Table 4.

Multivariate Cox proportional hazards analysis of overall survival

Variable	Univariate	Multivariate Analysis
Variable	P	P	HR	95% CI
Age at diagnosis	<0·0001	<0·0001	1·045	1·026–1·065
Clonal evolution at diagnosis	0·031	0·028	2·841	1·121–7·149
Sokal risk Score	0·15
Type of TKIs	0·45
Time from diagnosis to TKI	0·26
Cumulative response with a time dependent variable^*
CCyR	<0·0001	<0·0001	6·250	3·367–11·494
MMR	<0·0001	<0·0001	6·579	3·745–11·628
MR4·5	<0·0001	<0·0001	5·154	2·841–9·346
CMR	<0·0001	0·0013	3·003	1·538–5·882

Each variable was compared to the counterpart no response category and calculated for multivariate analysis separately.

Abbreviations: TKI, tyrosine kinase inhibitor; HR, hazard ratio; CI, confidence interval; CCyR, complete cytogenetic response; MMR, major molecular response; MR4·5, molecular response with 4·5 log reduction by international scale; CMR, complete molecular response; OS, overall survival.