Table 5.
One-year landmark by cumulative response within one year
| Group | No. at 5y |
5-y Absolute OS [95% CI] |
5-y Relative OS [95% CI] |
5-y OS in GP |
No. at 10y |
10-y Absolute OS [95% CI] |
10-y Relative OS [95% CI] |
10-y OS in GP |
|---|---|---|---|---|---|---|---|---|
| Age 15–84 | ||||||||
| All N=465 | 312 | 93·5 [91·0–95·9] | 95·1 [92·6–97·6] | 98·3 | 127 | 84·2 [79·9–88·6] | 88·4 [83·9–93·1] | 95·2 |
| CCyR N=413 | 284 | 95·2 [92·8–97·5] | 97·0 [94·6–99·4] | 98·1 | 115 | 87·7 [83·4–92·0] | 92·3 [87·8–96·8] | 95·0 |
| MMR N=338 | 234 | 97·3 [95·4–99·3] | 99·1 [97·1–101·1] | 98·2 | 91 | 89·9 [85·3–94·4] | 94·6 [89·8–99·4] | 95·0 |
| MR4·5 N=159 | 105 | 95·8 [92·1–99·4] | 97·8 [94·0–101·4] | 98·0 | 47 | 88·5 [81·9–95·0] | 93·5 [86·5–100·3] | 94·7 |
| CMR N=81 | 53 | 98·6 [95·8–100] | 100·5 [97·7–101·9] | 98·1 | 21 | 91·7 [82·2–100] | 96·8 [86·8–105·6] | 94·7 |
| Age 15–44 | ||||||||
| All N=189 | 131 | 96·2 [93·2–99·2] | 96·9 [93·9–99·9] | 99·3 | 48 | 90·0 [84·4–95·6] | 91·6 [85·9–97·4] | 98·2 |
| CCyR N=160 | 117 | 99·2 [97·7–100] | 99·9 [98·4–100·7] | 99·3 | 42 | 95·5 [90·9–100] | 97·3 [92·6–101·8] | 98·2 |
| MMR N=131 | 95 | 99·1 [97·2–100] | 99·8 [97·9–100·7] | 99·3 | 34 | 96·0 [91·4–100] | 97·9 [93·2–101·9] | 98·1 |
| MR4·5 N=60 | 41 | 100 | 100·7 | 99·3 | 19 | 97·0 [91·1–100] | 99·0 [93·0–102·0] | 98·0 |
| CMR N=32 | 21 | 100 | 100·7 | 99·3 | 10 | 100 | 102·1 | 97·9 |
| Age 45–64 | ||||||||
| All N=214 | 140 | 94·4 [90·9–97·8] | 97·0 [93·4–100·5] | 97·3 | 58 | 88·0 [82·4–93·6] | 94·7 [88·7–100·8] | 92·9 |
| CCyR N=196 | 130 | 96·1 [93·0–99·2] | 98·8 [95·6–102·0] | 97·3 | 54 | 92·0 [87·0–97·0] | 99·0 [93·6–104·4] | 92·9 |
| MMR N=164 | 110 | 98·5 [96·5–100] | 101·2 [99·2–102·8] | 97·3 | 43 | 94·6 [89·7–99·4] | 101·8 [96·6–107·0] | 92·9 |
| MR4·5 N=74 | 49 | 98·2 [94·8–100] | 100·7 [97·2–102·6] | 97·5 | 20 | 92·8 [84·7–100] | 99·5 [90·8–107·2] | 93·3 |
| CMR N=39 | 24 | 100 | 102·8 | 97·3 | 7 | 100 | 107·6 | 92·9 |
| Age 65–84 | ||||||||
| All N=62 | 41 | 82·7 [72·4–93·0] | 92·4 [80·9–103·9] | 89·5 | 21 | 60·9 [46·2–75·5] | 83·4 [63·6–104·0] | 72·6 |
| CCyR N=57 | 37 | 81·3 [70·2–92·3] | 90·8 [78·4–103·1] | 89·5 | 19 | 59·5 [44·0–74·9] | 82·0 [60·6–103·2] | 72·6 |
| MMR N=43 | 29 | 88·3 [77·5–99·1] | 99·7 [87·5–111·9] | 88.6 | 14 | 61·9 [43·6–80·3] | 88·9 [62·6–115·4] | 69·6 |
| MR4·5 N=25 | 15 | 80·0 [62·5–97·5] | 88·5 [69·1–107·9] | 90·4 | 8 | 61·7 [38·9–94·5] | 82·6 [52·1–126·5] | 74·7 |
| CMR N=10 | 8 | 88·9 [68·4–100] | 98·6 [75·8–110·9] | 90·2 | 4 | 61·0 [25·6–96·3] | 82·3 [34·5–130·0] | 74·1 |
Abbreviations: OS, overall survival; GP, general population; CI, confidence interval; CCyR, complete cytogenetic response; MMR, major molecular response; MR4·5, molecular response with 4·5 log reduction by international scale; CMR, complete molecular response.