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. 2016 Jun 1;27(11):1740–1752. doi: 10.1091/mbc.E15-09-0655

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© 2016 Zheng, Mennella, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Drosophila Nin (Bsg25D or CG14025) is the sole ortholog of mammalian Ninein and Ninein-like protein (Nlp). (A) The Ninein (Nin) family members share a highly conserved domain near the N-terminus that regulates microtubule assembly (shown as a green box), and multiple coiled-coil regions. Mammalian Nin has a centriole-targeting domain (red box) that is not conserved in Drosophila or in the mammalian paralog. The sequences corresponding to polypeptides used to raise antibodies are indicated. (B) Tree showing phylogenetic relationships among the Nin orthologues and paralogs. (C) Results of BLAST alignments show that Drosophila Nin has significant similarity to human Nin and Ninein-like protein (Nlp). Protein sequences conserved among Nin orthologues of metazoans are highlighted in red, and those conserved among Nlp orthologues are highlighted in blue. Note that Drosophila Nin shares residues with both Nin and Nlp (highlighted in green).