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. 2016 Jun 1;27(11):1753–1763. doi: 10.1091/mbc.E15-08-0577

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© 2016 Masuda and Toda. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Model for the synergistic role of Alp16^GCP6 and Mzt1 in spindle microtubule assembly. A model for the assembly of γTuSC and γTuRC rings at mitotic SPBs. (A) The γTuSC is recruited to Pcp1, the γTuC receptor at mitotic SPBs, where the γTuSC ring is assembled. Mzt1 is essential for this recruitment. (B) The γTuRC ring is assembled in the presence of Alp16^GCP6. Alp16^GCP6 binds to Gfh1^GCP4 and to Alp4^GCP2 or Alp6^GCP3 in the absence of Gfh1^GCP4. (C) The γTuRC ring is recruited to Pcp1 at mitotic SPBs in the presence of Mzt1. This recruitment occurs more efficiently than with γTuSC ring assembly at mitotic SPBs. (D) Alp16^GCP6 promotes γTuRC ring assembly at mitotic SPBs in the presence of Mzt1. (E) Mzt1 fully activates the γTuRC at mitotic SPBs.