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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neuropharmacology. 2015 Apr 29;95:377–387. doi: 10.1016/j.neuropharm.2015.04.015

Fig. 8.

Fig. 8

A: Effects induced by 20 min application of ACTZ (10 μM) on the isolated GABAergic field events occurring in the PC and EC during 20 min concomitant application of CPP + CNQX (10 μM each, n = 6 experiments). In panel A the initial control activity under 4AP treatment is characterized by a typical tonic-clonic ictal discharges in both PC and EC. Enlarged portion of these events shown in B during application of CPP + CNQX (10 μM each) and after application of ACTZ (10 μM). C: Bar graphs summarizing the change in duration, interval of occurrence and amplitude of the slow isolated GABAergic events under control conditions (i.e., 4AP + CPP + CNQX) and during further application of ACTZ (10 μM). Note that application of ACTZ (10 μM) decreases the duration, the rate of occurrence and the amplitude of these events. *p < 0.05, **p < 0.001, ***p < 0.0001.