Fig. 3.
Organ of Corti degeneration in Ap1g1fgt mutant mice. Mid-modiolar cross sections through the cochlea of +/+ control (a, b) and fgt/fgt mutant (c, d) mice were examined at 1 and 3 months of age. 1-month sections (a, c) are through the basal turn, and 3-month sections (b, c) are through the middle turn of the cochlea. Structural features of the cochlea are labeled in the 1-month +/+ section (a): Reissner’s membrane (rm), stria vascularis (sv), spiral ganglion cells (sgc), and organ of Corti (oc). The organ of Corti, labeled in all panels, is intact in 1- and 3-month-old controls (a, b) and in 1-month-old mutants (c), but has degenerated in 3-month-old mutants (d). All sections are shown at the same magnification; the black scale bar in panel A represents 200 micrometers