Fig. 5.

Retinal spots and choroidal neovascularization in Ap1g1^fgt mutant mice. The eye examination of the control mice (genotype: +/fgt) showed a normal retinal structure by OCT (a), normal fundus (b), no fluorescein leakage in the retina (c), and a normal retina by histology (d) at 6 weeks of age. But examination of the fgt/fgt mutant mice revealed the abnormal retina by OCT at 6 weeks of age (e) and at 16 weeks of age (i), a scattered depigmented spots fundus at 6 weeks of age (f), and the large depigmented areas fundus at 16 weeks of age (j). The fluorescein angiography showed the areas of leakage in the retina as a typical fluorescein angiographic pattern of CNV at 6 weeks of age (g) and at 16 weeks of age (k). The neovessels were detected by histology at 6 weeks of age (h) and at 16 weeks of age (l). Retinal layers are labeled in the +/fgt control mouse (d): GCL ganglion cell layer; IPL inner plexiform layer; INL inner nuclear layer; OPL outer plexiform layer; ONL outer nuclear layer; PIS photoreceptor inner segment; POS photoreceptor outer segment; RPE retina pigment epithelium