Fig. 6.
Thyroid gland pathology and its effects in Ap1g1fgt mutant mice. a, b Cross sections of thyroid glands stained with H&E from a 15-week-old +/fgt control (a) and an age-matched fgt/fgt mutant mouse (b). Thyroid glands of mutant mice have only a few normal follicles containing colloid material (asterisk in B) and have highly proliferating epithelial cells that give rise to adenomas (goiters). A and B are the same magnification; the black scale bar in B represents 100 micrometers. (c) Scatter plot of thyroxine (T4) levels in +/fgt control (15 females, 7 males) and fgt/fgt mutant mice (11 females, 12 males) from 3–40 weeks of age. Mutant mice have lower T4 levels than controls especially at younger ages. (d) The mean body weights (error bars, ± SEM) of female and male control and mutant mice were compared at 4–6 weeks of age