Table 1.

Influence of AGT on GS-IR cell density in the adult brain

	GS-IR cell density (×104 cells/mm3)
	Level	Control	AGTL	AGTH
SNc
Male	A	0.27 ± 0.01	0.65 ± 0.08*	0.55 ± 0.07
	B	0.42 ± 0.09	1.06 ± 0.31*	0.55 ± 0.02
	C	0.28 ± 0.04	1.10 ± 0.05*	0.38 ± 0.09
	D	0.39 ± 0.05	0.78 ± 0.17*	0.44 ± 0.07
Female	A	0.34 ± 0.04	0.69 ± 0.07*	0.44 ± 0.10
	B	0.54 ± 0.11	0.95 ± 0.15*	0.38 ± 0.09
	C	0.26 ± 0.02	0.62 ± 0.16*	0.27 ± 0.03
	D	0.28 ± 0.02	0.97 ± 0.25*	0.33 ± 0.13
VTA
Male	B	0.23 ± 0.02	0.72 ± 0.10*	0.44 ± 0.03
	C	0.36 ± 0.07	1.12 ± 0.11*	0.51 ± 0.09
	D	0.23 ± 0.02	0.69 ± 0.11*	0.32 ± 0.03
Female	B	0.22 ± 0.02	0.76 ± 0.10*	0.24 ± 0.04
	C	0.09 ± 0.01+	0.61 ± 0.23*,+	0.31 ± 0.06+
	D	0.28 ± 0.06	0.85 ± 0.11*	0.27 ± 0.04
SNr
Male	–	1.66 ± 0.23	2.01 ± 0.33	1.84 ± 0.12
Female	–	2.08 ± 0.19	2.20 ± 0.20	1.75 ± 0.37

Density of GS-IR cells throughout the SNc, VTA and SNr of male and female mice in adulthood following treatment with dexamethasone via the maternal drinking water prenatally on embryonic days 16–19 (AGT_L 0.5 µg/ml; AGT_H 1.0 µg/ml) compared to the control offspring of dams receiving normal drinking water. Data are mean ± SEM, n = 6 animals per treatment group

* Significant effect of treatment, p < 0.05 for dexamethasone-treated vs. control animals

⁺Significant sex difference, p < 0.05 vs. males in the same treatment group