Table 2.

Effects of thymoquinone on the induction of morphine dependence in mice

Drug (dose)	Number of jumps
Control	42.6 ± 9.4
Diazepam (4 mg/kg)	2.1 ± 0.2 ***
Thymoquinone (10 mg/kg)	27.0 ± 3.3
Thymoquinone (20 mg/kg)	16.4 ± 5.2 *
Thymoquinone (40 mg/kg)	0.3 ± 0.3 ***

Thymoquinone and controls were administered 30 min before the injection of naloxone (2 mg/kg, i.p.) on the fourth day. Control: Normal saline + Tween 80 (0.8%, v/v); Values are the mean ± SEM for 7 mice;

^*p<0.05,

^***p<0.001, as compared to control.