Table 6.
Effect of thymoquinone on motor coordination of mice in rotarod test
| Drug (dose) | Time-on-rod (s) | |
|---|---|---|
| 30 min after the injection of thymoquinone | 60 min after the injection of thymoquinone | |
| Control | 300 ± 0.0 | 300 ± 0.0 |
|
Diazepam
(4 mg/kg) |
3.7 ± 0.4 *** | 5.2 ± 0.8 *** |
|
Thymoquinone
(10 mg/kg) |
295.3 ± 2.3 | 294.9 ± 2.4 |
|
Thymoquinone
(20 mg/kg) |
282.9 ± 5.1 | 283.3 ± 4.6 |
|
Thymoquinone
(40 mg/kg) |
264.0 ± 11.7 * | 272.9 ± 12.9 |
Thymoquinone and control were administered 60 and 30 min prior to the test. Values are the length of time each animal remained on the rotating rod (time-on-rod). Control: Normal saline + Tween 80 (0.8%, v/v); Values are the mean ± SEM for 7 mice;
*
p<0.05,
***
p<0.001, as compared to control.