Supplementary Table.

Differential expression levels of miRNAs between CE-R and CE-NR libraries

mi-name	CE-sth	CENR-sth	Fold change	P value	Sig-lable
bta-miR-124a	3.21	17.15	2.42	0.00	**
bta-miR-124b	3.21	17.15	2.42	0.00	**
bta-miR-1307	56.33	121.36	1.11	0.00	**
bta-miR-130a	54.55	112.61	1.05	0.00	**
bta-miR-139	31.34	81.11	1.37	0.00	**
bta-miR-145	1827.12	4082.36	1.16	0.00	**
bta-miR-153	0.20	1.25	2.61	0.00	**
bta-miR-16a	46.29	94.28	1.03	0.00	**
bta-miR-16b	43.42	91.26	1.07	0.00	**
bta-miR-181b	334.00	734.81	1.14	0.00	**
bta-miR-181c	11.06	25.39	1.20	0.00	**
bta-miR-181d	62.54	139.47	1.16	0.00	**
bta-miR-18a	2.66	9.49	1.83	0.00	**
bta-miR-193a-3p	8.81	50.27	2.51	0.00	**
bta-miR-193a-5p	30.72	67.64	1.14	0.00	**
bta-miR-196b	18.37	36.87	1.01	0.00	**
bta-miR-202	0.41	1.18	1.52	0.02	*
bta-miR-20b	4.85	11.33	1.23	0.00	**
bta-miR-21-3p	1.57	16.27	3.37	0.00	**
bta-miR-223	57.62	121.66	1.08	0.00	**
bta-miR-22-5p	22.53	51.96	1.21	0.00	**
bta-miR-2284h-5p	0.68	1.69	1.31	0.01	*
bta-miR-2284k	0.27	1.99	2.86	0.00	**
bta-miR-2331-3p	0.27	1.77	2.69	0.00	**
bta-miR-2332	0.89	2.58	1.54	0.00	**
bta-miR-2384	0.27	1.18	2.11	0.00	**
bta-miR-296-5p	2.12	5.45	1.36	0.00	**
bta-miR-29c	472.06	1192.00	1.34	0.00	**
bta-miR-324	3.55	12.95	1.87	0.00	**
bta-miR-331-3p	7.99	66.68	3.06	0.00	**
bta-miR-339a	22.53	91.04	2.01	0.00	**
bta-miR-339b	0.96	4.20	2.13	0.00	**
bta-miR-33a	21.71	124.75	2.52	0.00	**
bta-miR-345-3p	16.86	60.35	1.84	0.00	**
bta-miR-345-5p	8.53	30.03	1.81	0.00	**
bta-miR-34a	2.12	6.99	1.72	0.00	**
bta-miR-365-3p	33.32	71.91	1.11	0.00	**
bta-miR-365-5p	1.50	3.83	1.35	0.00	**
bta-miR-375	1014.30	2087.55	1.04	0.00	**
bta-miR-378b	1.71	14.72	3.11	0.00	**
bta-miR-378c	14.68	166.11	3.50	0.00	**
bta-miR-424-5p	21.30	47.91	1.17	0.00	**
bta-miR-449a	1.16	3.02	1.38	0.00	**
bta-miR-455-3p	27.58	57.55	1.06	0.00	**
bta-miR-490	5.12	11.70	1.19	0.00	**
bta-miR-532	18.16	42.91	1.24	0.00	**
bta-miR-542-5p	0.01	1.18	6.88	0.00	**
bta-miR-551b	0.48	1.40	1.55	0.01	*
bta-miR-582	0.48	1.47	1.62	0.01	**
bta-miR-6123	0.82	3.24	1.98	0.00	**
bta-miR-652	9.15	20.31	1.15	0.00	**
bta-miR-671	0.07	2.65	5.28	0.00	**
bta-miR-708	45.40	108.12	1.25	0.00	**
bta-miR-874	0.96	5.96	2.64	0.00	**
bta-miR-877	5.05	10.16	1.01	0.00	**
bta-miR-99a-3p	4.16	9.35	1.17	0.00	**
oar-miR-106a	3.21	8.61	1.42	0.00	**
oar-miR-10a	1912.32	4800.10	1.33	0.00	**
oar-miR-127	46.70	93.54	1.00	0.00	**
oar-miR-134-5p	0.14	1.84	3.75	0.00	**
oar-miR-154a-3p	1.09	3.09	1.50	0.00	**
oar-miR-16b	445.16	1302.77	1.55	0.00	**
oar-miR-181a	939.13	2073.34	1.14	0.00	**
oar-miR-27a	29.50	273.12	3.21	0.00	**
oar-miR-299-5p	1.37	2.80	1.03	0.01	**
oar-miR-30a-3p	45.20	91.19	1.01	0.00	**
oar-miR-376b-3p	3.62	12.44	1.78	0.00	**
oar-miR-376c-3p	4.57	13.17	1.53	0.00	**
oar-miR-376e-3p	4.92	13.91	1.50	0.00	**
oar-miR-487b-3p	12.77	33.86	1.41	0.00	**
oar-miR-494-3p	10.65	24.14	1.18	0.00	**
oar-miR-495-3p	16.11	38.86	1.27	0.00	**
oar-miR-539-3p	1.09	2.28	1.06	0.01	*
oar-miR-665-3p	0.27	1.18	2.11	0.00	**
bta-miR-1247-5p	0.55	1.40	1.36	0.02	*
bta-miR-216b	2.39	0.81	-1.56	0.00	**
bta-miR-217	1.64	0.44	-1.89	0.00	**
bta-miR-2284m	1.02	0.07	-3.80	0.00	**
bta-miR-2331-5p	5.33	2.50	-1.09	0.00	**
bta-miR-3141	1.84	0.88	-1.06	0.03	*
bta-miR-328	2.73	1.32	-1.04	0.01	**
bta-miR-3432	21.37	10.67	-1.00	0.00	**
bta-miR-484	13.52	6.18	-1.13	0.00	**

Note: CE-R represented the normalized expression level of miRNAs in the small intestine RNA library generated from CE sheep infected with E. granulosus infection.

CE-NR represented the normalized expression level of miRNAs in the small intestine RNA library generated from CE-NR sheep with E. granulosus infection.

Fold (R/P) and log2 (R/P) indicated the fold change of the miRNAs between samples. P-Value manifested the significance of miRNAs differential expression between two samples (*: P < 0.05; **: P < 0.01).