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. 2016 Mar 2;18(3):e23814. doi: 10.5812/ircmj.23814

Table 1. The Effect of the Oral Administration of Metformin, Acarbose, and Their Combination on Fasting Blood Glucose Levels and Glycated Hemoglobin in Normal and Nicotinamide/Streptozotocin-induced Type 2 Diabetic Ratsa,b.

Group Serum Glucose Levels, mg/dL HbA1c
Day 0 Day 42
Normal 69.3 ± 3.90 77.1 ± 3.90 4.46 ± 0.27
Diabetic control 269.8 ± 22.0c 295.8 ± 27.0c 7.25 ± 0.79c
Diabetic + metformin 307.0 ± 18.8c 105.8 ± 11.3c,d 4.91 ± 0.44d
Diabetic + acarbose 277.1 ± 19.0c 89.1 ± 6.3d 4.21 ± 0.17d
Diabetic + metformin and acarbose 258.6 ± 32.0c 68.3 ± 2.9d 3.80 ± 0.32d

aEach value is the mean ± SD of the six rats in each group.

bA1c, diabetic control group compared with all other groups after day 42 (P = 0.0001); FBS, diabetic control group compared with all other groups after day 42 (P = 0.0001).

cP < 0.05 as compared with normal rats.

dP < 0.05 in comparison with diabetic rats.