Table 1. The Effect of the Oral Administration of Metformin, Acarbose, and Their Combination on Fasting Blood Glucose Levels and Glycated Hemoglobin in Normal and Nicotinamide/Streptozotocin-induced Type 2 Diabetic Ratsa,b.
Group | Serum Glucose Levels, mg/dL | HbA1c | |
---|---|---|---|
Day 0 | Day 42 | ||
Normal | 69.3 ± 3.90 | 77.1 ± 3.90 | 4.46 ± 0.27 |
Diabetic control | 269.8 ± 22.0c | 295.8 ± 27.0c | 7.25 ± 0.79c |
Diabetic + metformin | 307.0 ± 18.8c | 105.8 ± 11.3c,d | 4.91 ± 0.44d |
Diabetic + acarbose | 277.1 ± 19.0c | 89.1 ± 6.3d | 4.21 ± 0.17d |
Diabetic + metformin and acarbose | 258.6 ± 32.0c | 68.3 ± 2.9d | 3.80 ± 0.32d |
aEach value is the mean ± SD of the six rats in each group.
bA1c, diabetic control group compared with all other groups after day 42 (P = 0.0001); FBS, diabetic control group compared with all other groups after day 42 (P = 0.0001).
cP < 0.05 as compared with normal rats.
dP < 0.05 in comparison with diabetic rats.