Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Clin Chest Med. 2016 Feb 20;37(2):219–229. doi: 10.1016/j.ccm.2016.01.004

Table 2. Overview of studies of the evolving clinical definitions of sepsis and recommended treatment.

Reference Institutions N Design Setting Illness Primary outcome Result
1992 Bone [25] United States (US) N/A Consensus conference N/A Sepsis Formal definition of sepsis Consensus definition established
2001 Rivers [26] 1 (US) 263 Interventional (randomized) ED Severe sepsis & Septic shock Early goal-directed therapy (EGDT) EGDT demonstrated to significantly reduce mortality
2004 Dellinger [27] International N/A Consensus guidelines N/A Severe sepsis & Septic shock Surviving Sepsis Campaign - 2004 Consensus definition established
2008 Dellinger [28] International N/A Consensus guidelines N/A Severe sepsis & Septic shock Surviving Sepsis Campaign - 2008 Consensus definitions updated
2013 Dellinger [29] International N/A Consensus guidelines N/A Severe sepsis & Septic shock Surviving Sepsis Campaign - 2012 Consensus definitions updated
2014 Yealy [29] 31 (US) 1341 Interventional (randomized & controlled) ED Early septic shock Reevaluation of EGDT “Early” (E) demonstrated to reduce mortality, but not “goal-directed” (GD)
2014 Peake [30] 51 (Australia & New Zealand) 1600 Interventional (randomized & controlled) ED Early septic shock Reevaluation of EGDT “Early” (E) demonstrated to reduce mortality, but not “goal-directed” (GD)
2015 Mouncey [31] 56 (England) 1260 Interventional (randomized & controlled) Any (post-ED admission) Early septic shock Reevaluation of EGDT “Early” (E) demonstrated to reduce mortality, but not “goal-directed” (GD)
2015 Kaukonen [32] 172 (Australia & New Zealand) 109663 Retrospective ICU Severe sepsis Diagnostic value of SIRS criteria A significant portion of severe sepsis patients are “SIRS negative”