Table 2.

Comparison of mRNA levels of APE1, OGG1, Polβ and PARP1 in different brain regions of AD patients (AD) and healthy controls (HC)

Base excision repair enzyme	Reference brain part	Compared brain part	AD p-value	HC p-value
APE1	Frontal cortex	Cerebellum	0.88	0.2
	Frontal cortex	Hippocampus	0.23	0.8
	Frontal cortex	Entorhinal cortex	0.8	0.3
	Cerebellum	Hippocampus	0.27	0.58
	Cerebellum	Entorhinal cortex	0.68	0.77
	Hippocampus	Entorhinal cortex	0.18	0.68
OGG1	Frontal cortex	Cerebellum	0.11	0.55
	Frontal cortex	Hippocampus	0.66	0.83
	Frontal cortex	Entorhinal cortex	0.6	0.67
	Cerebellum	Hippocampus	0.4	0.6
	Cerebellum	Entorhinal cortex	0.31	0.87
	Hippocampus	Entorhinal cortex	0.99	0.77
Polβ	Frontal cortex	Cerebellum	0.002 **	0.005**
	Frontal cortex	Hippocampus	0.34	0.21
	Frontal cortex	Entorhinal cortex	0.23	0.54
	Cerebellum	Hippocampus	0.00005****	0.01**
	Cerebellum	Entorhinal cortex	0.0002****	0.005**
	Hippocampus	Entorhinal cortex	0.78	0.17
PARP1	Frontal cortex	Cerebellum	0.77	0.64
	Frontal cortex	Hippocampus	0.96	0.44
	Frontal cortex	Entorhinal cortex	0.66	0.43
	Cerebellum	Hippocampus	0.84	0.38
	Cerebellum	Entorhinal cortex	0.47	0.37
	Hippocampus	Entorhinal cortex	0.67	0.92

p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001