Table 3.
Association of clinical diagnosis, CSF biomarkers and age with mRNA levels ofAPE1, OGG1, Polβ and PARP1 in blood
| Clinical determinant Diagnosis |
Base Excision Repair Enzyme | Association recorded | p-value |
|---|---|---|---|
| AD dementia | APE1 | 0.04 | 0.598 |
| MCI/AD | −0.06 | 0.508 | |
| MCI | −0.06 | 0.425 | |
| SCI | 0.05 | 0.570 | |
| AD dementia | OGG1 | −0.13 | 0.0324 * |
| MCI/AD | −0.13 | 0.0410 * | |
| MCI | −0.15 | 0.0083 ** | |
| SCI | −0.08 | 0.1941 | |
| AD dementia | Polβ | 0.22 | 0.0395 * |
| MCI/AD | 0.12 | 0.3165 | |
| MCI | 0.03 | 0.7295 | |
| SCI | 0.11 | 0.3235 | |
| AD dementia | PARP1 | 0.27 | 0.018 * |
| MCI/AD | 0.46 | 0.00014 *** | |
| MCI | 0.33 | 0.00150 ** | |
| SCI | 0.48 | 0.00007 **** | |
| CSF biomarkers | |||
| No CSF pathology | APE1 | −0.05 | 0.492 |
| Tau pathology | 0.09 | 0.320 | |
| Aβ pathology | −0.08 | 0.453 | |
| Tau and Aβ pathology | 0.02 | 0.856 | |
| No CSF pathology | OGG1 | −0.12 | 0.0164 * |
| Tau pathology | −0.17 | 0.0103 * | |
| Aβ pathology | −0.14 | 0.0468 * | |
| Tau and Aβ pathology | −0.09 | 0.1826 | |
| No CSF pathology | Polβ | 0.02 | 0.8508 |
| Tau pathology | 0.25 | 0.0352 * | |
| Aβ pathology | 0.14 | 0.2794 | |
| Tau and Aβ pathology | 0.19 | 0.1180 | |
| No CSF pathology | PARP1 | 0.43 | 0.00002 **** |
| Tau pathology | 0.40 | 0.0013 ** | |
| Aβ pathology | 0.38 | 0.0053 ** | |
| Tau and Aβ pathology | 0.32 | 0.0089 ** | |
| Age | |||
| Change over time: average effect per year | APE1 | −0.004 | 0.14 |
| OGG1 | −0.0006 | 0.768 | |
| PARP1 | −0.009 | 0.0196 * | |
| Polβ | 0.010 | 0.00599 ** | |
The parameters are compared to healthy controls. p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001