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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Trends Neurosci. 2016 Apr 12;39(6):378–393. doi: 10.1016/j.tins.2016.03.005

Figure 3.

Figure 3

Regulation of Neural Cells by the CSF-1R. Studies with purified neural progenitor cells (NPCs) show that the CSF-1R promotes NPC survival, proliferation, and differentiation towards the neuronal lineage in a cell-autonomous manner. The expanded panel illustrates CSF-1R support of the development of deep-layer and layer I neurons and suppression of layer II–IV (Satb2+) neurons. In the cerebellum, CSF-1 promotes the survival of Purkinje cells (PC) [12]. CSF-1R signaling in microglia, but not in purified NPCs, promotes oligodendrocyte differentiation (expanded panel). The lack of callosal axonal crossing defects and olfactory bulb (OB) atrophy in mice with NPC-specific ablation of CSF-1R expression suggests that microglia also mediate the effects of the CSF-1R in callosal and olfactory bulb development.