Table 1.

Comprehensive behavioral characterization of Cuprizone short-exposure mice.

Dimensions	Index	Test	Results	RDoC Domains/Constructs and sub-constructs
Motor systems	Motor coordination/learning	Rotarod	Normal, Fig.1	Unclassifiable
Memory	Recognition memory	NORT	↓, [1]	Cognitive Systems/Declarative Memory
	Spontaneous alternation	Y-maze	↓, [1]	Cognitive Systems/Perception
	Context/cue-induced fear Fear extinction	FC	Normal, Fig.2A	Negative Valence Systems/Responses to acute threat (Fear)
Executive function	Behavioral flexibility	RL	Normal, Fig.2B	Cognitive Systems/Cognitive Control
Social cognition	Sociability/social novelty	SIT	Normal, Fig.2C	Systems for Social Processes/Affiliation and Attachment
Anxiety	Neophobia	LDT	↑ (p=0.05), Fig.3A	Negative Valence Systems/Responses to potential harm (Anxiety)
	Hyponeophagia	NSFT	Normal, Fig.3B	Negative Valence Systems/Responses to potential harm (Anxiety)
Depression	Behavioral despair	FST	Normal, Fig.3C	Negative Valence Systems/Responses to sustained threat
	Behavioral despair	TST	Normal, Fig.3D	Negative Valence Systems/Responses to sustained threat
Psychosis	Sensitivity to psychostimulants	OF	↑, Fig.4 and [1]	Arousal and Regulatory Systems/Arousal
Information processing	Sensorimotor gating	PPI	Normal, [1]	Cognitive Systems/Perception

[1], Tezuka et al., 2013

NORT, Novel object recognition test; FC, Fear conditioning; RL, Reversal learning; SIT, Social interaction test; LDT, Light/dark box test; NSFT, Novelty suppressed feeding test; FST, Forced swim test; TST, Tail suspension test; OF, Open field; PPI, Prepulse inhibition